人参皂甙 Rh1
人参皂甙 Rh1(Ginsenoside Rh1)
CAS: 63223-86-9
化学式: C36H62O9
| 中文名 | 人参皂甙 Rh1 |
| 英文名 | Ginsenoside Rh1 |
| 别名 | 人参皂荚RH1 人参皂甙 Rh1 人参皂苷-RH1 人参皂苷 S-RH1 (R型)人参皂苷RH1 (S型)人参皂苷RH1 人参皂苷RH1(标准品) 人参皂苷RH1, 来源于人参 |
| 英文别名 | Ginsenoside Rh1 GINSENOSIDE RH1 sanchinoside rh1 Sanchinoside Rh1 Ginsenoside Rh1 (Prosapogenin A2 6α-(β-D-Glucopyranosyloxy)-dammara-24-ene-3β,12β,20-triol (20S)-6α-(β-D-Glucopyranosyloxy)dammar-24-ene-3β,12β,20-triol 3β,12β,20-Trihydroxy-5α-dammar-24-en-6α-yl β-D-glucopyranoside (20S)-6α-(β-D-Glucopyranosyloxy)-3β,12β,20-trihydroxydammara-24-ene (3beta,6alpha,12beta)-3,12,20-Trihydroxydammar-24-en-6-yl beta-D-glucopyranoside (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl?beta-d-glucopyranoside (3beta,6alpha,9xi,12beta,13xi)-3,12,20-trihydroxydammar-24-en-6-yl beta-D-glucopyranoside |
| CAS | 63223-86-9 |
| 化学式 | C36H62O9 |
| 分子量 | 638.88 |
| InChI | InChI=1/C36H62O9/c1-19(2)10-9-13-36(8,43)20-11-15-34(6)26(20)21(38)16-24-33(5)14-12-25(39)32(3,4)30(33)22(17-35(24,34)7)44-31-29(42)28(41)27(40)23(18-37)45-31/h10,20-31,37-43H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24+,25-,26-,27+,28-,29+,30-,31+,33+,34+,35+,36-/m0/s1 |
| 密度 | 1.23 |
| 沸点 | 755.1±60.0 °C(Predicted) |
| 比旋光度 | (c, 0.88 in MeOH)+20 |
| 闪点 | 410.457°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | 易溶于水、甲醇、乙醇，不溶于石油醚、乙醚、苯。 |
| 折射率 | 1.581 |
| 酸度系数 | 12.91±0.70(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 白色结晶性粉末 |
| 物化性质 | 白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参。 |
| MDL号 | MFCD09951797 |
| 体外研究 | The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected. |
| 体内研究 | When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone. |
| 参考资料 展开查看 | 1. 钟雅婷 茅仁刚 宋纯清 等. RP-HPLC同时测定西洋参总皂苷转化产物中人参皂苷Rg1 Rh1 Rd Rg3和C-K的含量[J]. 江西中医药 2012 43(8):61-64. 2. 董坤园, 于澎, 熊金路,等. 基于高效液相色谱图谱结合化学计量学的红参指纹图谱研究[J]. 食品安全质量检测学报, 2019, 010(021):7316-7321. 3. 张博, 孙秀丽, 郭云龙,等. 液质联用技术分析不同产地不同年限人参的化学成分[J]. 中国实验方剂学杂志, 2020年26卷8期, 206-212页, ISTIC PKU CSCD CA, 2020. 4. 张琰, 李方彤, 韩铭鑫,等. 通过RRLC-Q-TOF MS和UPLC-QQQ MS分析原人参三醇型皂苷在人肠道菌群中的代谢产物[J]. 质谱学报, 2020(1):66-75. 5. 夏晚霞, 张尚微, 葛亚中,等. 乳酸菌发酵转化人参皂苷[J]. 现代食品科技, 2018, 34(09):136-142. 6. 越皓,周东月,张美玉,张琰,戴雨霖,郑飞,朱英豪.红参中原人参三醇型皂苷组在肠道菌群中体外转化及对肠道菌群的作用[J].应用化学,2021,38(03):323-330. 7. Zhang, Hong-Mei, et al. "Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach." Journal of pharmaceutical and biomedical analysis 62 (2012): 258-273.https://doi.org/10.1016/j.jpba.2012.01.010 8. Qin, Z., Jia, M., Yang, J. et al. Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions. Chin Med 15, 69 (2020). https://doi.o 9. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 10. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 11. 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产品名: 人参皂苷Rh1 标准品 去供应商网站查看 询盘CAS: 63223-86-9
产地: 北京
包装: 瓶
规格: SG8390-20mg,20mg,IG0270-D-1ml,10mM*1ml(inDMSO),IG0270-10mg,10mg,IG0270-20mg,20mg
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现货供应
产品名: 人参皂苷Rh1 标准品 去供应商网站查看 询盘CAS: 63223-86-9
产地: 北京
包装: 瓶
规格: SG8390-20mg,20mg,IG0270-D-1ml,10mM*1ml(inDMSO),IG0270-10mg,10mg,IG0270-20mg,20mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
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